Bromide ion → 3-[1-(3-Benzyloxy-phenyl)-8-chloro-imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol

HRID 1569672Notes

Reaction equation

HRID 1569672 reaction equation
[Br-:30].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](-[c:15]2[n:16][c:17]([CH:25]3[CH2:26][C:27](=[O:29])[CH2:28]3)[n:18]3[c:19]2[c:20]([Cl:24])[n:21][cH:22][cH:23]3)[cH:12][cH:13][cH:14]1.[CH2:33]1[O:34][CH2:35][CH2:36][CH2:37]1.[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:31][Mg+:32].[CH3:38][c:39]1[cH:40][cH:41][cH:42][cH:43][cH:44]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[cH:10][c:11](-[c:15]2[n:16][c:17]([CH:25]3[CH2:26][C:27]([OH:29])([CH3:31])[CH2:28]3)[n:18]3[c:19]2[c:20]([Cl:24])[n:21][cH:22][cH:23]3)[cH:12][cH:13][cH:14]1

Participants

6

Reactant 5

HCID 259Bromide ionHCID 1140TolueneHCID 8028Tetrahydrofuran2×HCID 598528193-{1-[3-(Benzyloxy)phenyl]-8-chloroimidazo[1,5-a]pyrazin-3-yl}cyclobutanoneHCID 178477777HCID 178477777, compound

Product 1

HCID 598527383-[1-(3-Benzyloxy-phenyl)-8-chloro-imidazo[1,5-a]pyrazin-3-yl]-1-methyl-cyclobutanol

Sources & evidence

ORD record
ord-f532b87db8e9474bbb53c69ac145b19f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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