Acetate → 4-(4-Amino-3-cyclohex-1-enyl-phenyl)-1-methyl-piperidine-2,6-dione

HRID 1569714Notes

Reaction equation

HRID 1569714 reaction equation
[C:26]1([B:32]([OH:33])[OH:34])=[CH:27][CH2:28][CH2:29][CH2:30][CH2:31]1.[CH3:60][c:61]1[cH:62][cH:63][cH:64][cH:65][cH:66]1.[CH3:67][CH2:68][O:69][C:70]([CH3:71])=[O:72].[CH:35]1([P:36]([CH:37]2[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42]2)[c:43]2[cH:44][cH:45][cH:46][cH:47][c:48]2-[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[CH2:55][CH2:56][CH2:57][CH2:58][CH2:59]1.[K+:23].[K+:24].[K+:25].[NH2:1][c:2]1[c:3]([Br:17])[cH:4][c:5]([CH:8]2[CH2:9][C:10](=[O:16])[N:11]([CH3:15])[C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1.[O-:74][C:75]([CH3:76])=[O:77].[O-:78][C:79]([CH3:80])=[O:81].[O:82]1[CH2:83][CH2:84][O:85][CH2:86][CH2:87]1.[P:18]([O-:19])([O-:20])([O-:21])=[O:22].[Pd+2:73]>>[NH2:1][c:2]1[c:3]([C:26]2=[CH:27][CH2:28][CH2:29][CH2:30][CH2:31]2)[cH:4][c:5]([CH:8]2[CH2:9][C:10](=[O:16])[N:11]([CH3:15])[C:12](=[O:14])[CH2:13]2)[cH:6][cH:7]1

Participants

11

Reactant 10

HCID 175Acetate2×HCID 813Potassium Cation3×HCID 1061PhosphateHCID 1140TolueneHCID 8857Ethyl AcetateHCID 312751,4-DioxaneHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27342162-(Dicyclohexylphosphino)biphenylHCID 38629021-Cyclohexenylboronic acidHCID 597712194-(4-Amino-3-bromo-phenyl)-1-methyl-piperidine-2,6-dione

Product 1

HCID 597712664-(4-Amino-3-cyclohex-1-enyl-phenyl)-1-methyl-piperidine-2,6-dione

Sources & evidence

ORD record
ord-e927c3ad060f4cee97351aed378cd57a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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