Tetrahydrofuran → 2-benzyl-2-(1-triisopropylsilanyl-1H-indole-5-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester
Reaction equation
[Br:1][c:2]1[cH:3][c:4]2[cH:5][cH:6][n:7]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:8]2[cH:9][cH:10]1.[C:21]([Li:22])([CH3:23])([CH3:24])[CH3:25].[CH2:49]1[O:50][CH2:51][CH2:52][CH2:53]1.[CH3:26][O:27][C:28](=[O:29])[C:30]1([CH2:42][c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[N:31]([C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:32][CH2:33][CH2:34]1>>[c:2]1([C:28](=[O:27])[C:30]2([CH2:42][c:43]3[cH:44][cH:45][cH:46][cH:47][cH:48]3)[N:31]([C:35](=[O:36])[O:37][C:38]([CH3:39])([CH3:40])[CH3:41])[CH2:32][CH2:33][CH2:34]2)[cH:3][c:4]2[cH:5][cH:6][n:7]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:8]2[cH:9][cH:10]1Participants
5
Sources & evidence
- ORD record
- ord-b9c91582375f4b36ad01ec6188b04e7e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
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