Tetraethylammonium → Tert-butyl 3-[1-(3-chlorophenyl)-1-(2-hydroxyethoxy)ethyl]piperidine-1-carboxylate

HRID 1571209Notes

Reaction equation

HRID 1571209 reaction equation
[C:1]([Si:2]([CH3:3])([CH3:4])[O:6][CH2:7][CH2:8][O:9][C:10]([CH3:11])([c:12]1[cH:13][c:14]([Cl:18])[cH:15][cH:16][cH:17]1)[CH:19]1[CH2:20][N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:22][CH2:23][CH2:24]1)([CH3:5])([CH3:32])[CH3:33].[CH2:35]([N+:36]([CH2:37][CH3:38])([CH2:39][CH3:40])[CH2:41][CH3:42])[CH3:43].[CH3:44][C:45]#[N:46].[F-:34]>>[OH:6][CH2:7][CH2:8][O:9][C:10]([CH3:11])([c:12]1[cH:13][c:14]([Cl:18])[cH:15][cH:16][cH:17]1)[CH:19]1[CH2:20][N:21]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:22][CH2:23][CH2:24]1

Participants

5

Reactant 4

HCID 5413TetraethylammoniumHCID 6342AcetonitrileHCID 28179Fluoride IonHCID 72529628Tert-butyl 3-[1-[2-[tert-butyl(dimethyl)silyl]oxyethoxy]-1-(3-chlorophenyl)ethyl]piperidine-1-carboxylate

Product 1

HCID 72529657Tert-butyl 3-[1-(3-chlorophenyl)-1-(2-hydroxyethoxy)ethyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-882ca710241d4c2ea03ef127e1e3d252
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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