Pyridine → N-[5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

HRID 157250Notes

Reaction equation

HRID 157250 reaction equation
[CH:27]1([C:30](=[O:31])[Cl:32])[CH2:28][CH2:29]1.[NH2:1][c:2]1[s:3][c:4]2[n:5][c:6]([N:11]([c:12]3[cH:13][cH:14][c:15]([F:25])[c:16]([NH:18][C:19]([C:20]([F:21])([F:22])[F:23])=[O:24])[cH:17]3)[CH3:26])[cH:7][cH:8][c:9]2[n:10]1.[cH:33]1[cH:34][cH:35][n:36][cH:37][cH:38]1>>[NH:1]([c:2]1[s:3][c:4]2[n:5][c:6]([N:11]([c:12]3[cH:13][cH:14][c:15]([F:25])[c:16]([NH:18][C:19]([C:20]([F:21])([F:22])[F:23])=[O:24])[cH:17]3)[CH3:26])[cH:7][cH:8][c:9]2[n:10]1)[C:30]([CH:27]1[CH2:28][CH2:29]1)=[O:31]

Participants

4

Reactant 3

HCID 1049PyridineHCID 77637Cyclopropanecarbonyl chlorideHCID 86646057N-{5-[(2-amino[1,3]thiazolo[5,4-b]pyridin-5-yl)(methyl)amino]-2-fluorophenyl)-2,2,2-trifluoroacetamide

Product 1

HCID 86646058N-[5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Sources & evidence

ORD record
ord-a33b0b4825744c9599782fd961373feb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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