Hydrochloric Acid → Ethyl 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,3-thiazole-5-carboxylate

HRID 1572544Notes

Reaction equation

HRID 1572544 reaction equation
[Cl:1][c:2]1[c:3]([C:9](=[O:10])[NH:11][CH:12]2[CH2:13][CH2:14][N:15]([c:16]3[s:17][c:18]([C:19]#[N:20])[c:21]([OH:22])[n:23]3)[CH2:24][CH2:25]2)[nH:4][c:5]([CH3:8])[c:6]1[Cl:7].[ClH:26].[NH2:27][CH:28]1[CH2:29][CH2:30][N:31]([c:34]2[s:35][c:36]([C:51](=[O:52])[O:53][CH2:54][CH3:55])[c:37]([CH2:39][N:40]3[C:41](=[O:50])[c:42]4[cH:43][cH:44][cH:45][cH:46][c:47]4[C:48]3=[O:49])[n:38]2)[CH2:32][CH2:33]1>>[Cl:1][c:2]1[c:3]([C:9](=[O:10])[NH:27][CH:28]2[CH2:29][CH2:30][N:31]([c:34]3[s:35][c:36]([C:51](=[O:52])[O:53][CH2:54][CH3:55])[c:37]([CH2:39][N:40]4[C:41](=[O:50])[c:42]5[cH:43][cH:44][cH:45][cH:46][c:47]5[C:48]4=[O:49])[n:38]3)[CH2:32][CH2:33]2)[nH:4][c:5]([CH3:8])[c:6]1[Cl:7]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 685798543,4-dichloro-N-[1-(5-cyano-4-hydroxy-1,3-thiazol-2-yl)piperidin-4-yl]-5-methyl-1H-pyrrole-2-carboxamideHCID 68579925Ethyl 2-(4-aminopiperidin-1-yl)-4-[(1,3-dioxoisoindol-2-yl)methyl]-1,3-thiazole-5-carboxylate

Product 1

HCID 68579992Ethyl 2-(4-{[(3,4-dichloro-5-methyl-1H-pyrrol-2-yl)carbonyl]amino}piperidin-1-yl)-4-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]-1,3-thiazole-5-carboxylate

Sources & evidence

ORD record
ord-43c215848def4a66bc3016dfaedfb51f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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