Dichloromethane → 2-Oxo-1-piperidin-4-yl-2,3-dihydro-1H-imidazole-4-carbonitrile

HRID 1572723Notes

Reaction equation

HRID 1572723 reaction equation
[C:8](#[N:9])[c:10]1[nH:11][c:12](=[O:28])[n:13]([CH:15]2[CH2:16][CH2:17][N:18]([C:21]([O:22][C:23]([CH3:24])([CH3:25])[CH3:26])=[O:27])[CH2:19][CH2:20]2)[cH:14]1.[Cl:29][CH2:30][Cl:31].[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[C:8](#[N:9])[c:10]1[nH:11][c:12](=[O:28])[n:13]([CH:15]2[CH2:16][CH2:17][NH:18][CH2:19][CH2:20]2)[cH:14]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59006363Tert-butyl 4-(4-cyano-2-oxo-2,3-dihydroimidazol-1-yl)piperidine-1-carboxylate

Product 1

HCID 598565282-Oxo-1-piperidin-4-yl-2,3-dihydro-1H-imidazole-4-carbonitrile

Sources & evidence

ORD record
ord-08c70421aec6454bb9c4e938a0d7f2dd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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