Hydroxide → 2-Fluoro-3-(tetrahydro-2H-pyran-4-yl)pyridine

HRID 1573440Notes

Reaction equation

HRID 1573440 reaction equation
[CH3:14][CH2:15][O:16][C:17]([CH3:18])=[O:19].[O:1]1[CH2:2][CH2:3][C:4]([c:7]2[c:8]([F:13])[n:9][cH:10][cH:11][cH:12]2)=[CH:5][CH2:6]1.[OH-:20].[OH-:22].[Pd+2:21]>>[O:1]1[CH2:2][CH2:3][CH:4]([c:7]2[c:8]([F:13])[n:9][cH:10][cH:11][cH:12]2)[CH2:5][CH2:6]1

Participants

5

Reactant 4

HCID 961Hydroxide2×HCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 593267823-(3,6-dihydro-2H-pyran-4-yl)-2-fluoropyridine

Product 1

HCID 593271552-Fluoro-3-(tetrahydro-2H-pyran-4-yl)pyridine

Sources & evidence

ORD record
ord-ccee04452da1416a8fedcfb0129a5046
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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