Dichloromethane → 2-Amino-N-(1-benzylpiperidin-4-yl)-3-fluorobenzamide

HRID 157369Notes

Reaction equation

HRID 157369 reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:16])[c:17]2[c:18]([NH:24][C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[c:19]([F:23])[cH:20][cH:21][cH:22]2)[CH2:12][CH2:13]1.[Cl:39][CH2:40][Cl:41].[OH:32][C:33]([C:34]([F:35])([F:36])[F:37])=[O:38]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15](=[O:16])[c:17]2[c:18]([NH2:24])[c:19]([F:23])[cH:20][cH:21][cH:22]2)[CH2:12][CH2:13]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 59639684tert-Butyl 2-(1-benzylpiperidin-4-ylcarbamoyl)-6-fluorophenylcarbamate

Product 1

HCID 211021192-Amino-N-(1-benzylpiperidin-4-yl)-3-fluorobenzamide

Sources & evidence

ORD record
ord-43c845b5674a4bb99bfaf6d5a451ddc3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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