Ammonium → tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate

HRID 1574033Notes

Reaction equation

HRID 1574033 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:23]#[N:24])[cH:16][c:17]([N+:20]([O-:21])=[O:22])[cH:18][cH:19]2)[CH2:12][CH2:13]1.[CH3:27][OH:28].[Cl-:25].[NH4+:26].[Zn:29]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][N:11]([c:14]2[c:15]([C:23]#[N:24])[cH:16][c:17]([NH2:20])[cH:18][cH:19]2)[CH2:12][CH2:13]1

Participants

6

Reactant 5

HCID 223AmmoniumHCID 312ChlorideHCID 887MethanolHCID 23994ZincHCID 22227995tert-Butyl 4-(2-cyano-4-nitrophenyl)piperazine-1-carboxylate

Product 1

HCID 22227872tert-Butyl 4-(4-amino-2-cyanophenyl)piperazine-1-carboxylate

Sources & evidence

ORD record
ord-4c5bf8a24b3b43eca74d88c40bdf1ffe
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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