Dichloromethane → 1-(4-(Azetidin-3-yloxy)-2-fluorobenzyl)-4-methylpiperazine

HRID 1574821Notes

Reaction equation

HRID 1574821 reaction equation
[Cl:35][CH2:36][Cl:37].[F:1][c:2]1[cH:3][c:4]([O:5][CH:6]2[CH2:7][N:8]([C:10]([O:11][C:12]([CH3:13])([CH3:14])[CH3:15])=[O:16])[CH2:9]2)[cH:17][cH:18][c:19]1[CH2:20][N:21]1[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1.[F:28][C:29]([F:30])([F:31])[C:32]([OH:33])=[O:34]>>[F:1][c:2]1[cH:3][c:4]([O:5][CH:6]2[CH2:7][NH:8][CH2:9]2)[cH:17][cH:18][c:19]1[CH2:20][N:21]1[CH2:22][CH2:23][N:24]([CH3:27])[CH2:25][CH2:26]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 58043154tert-Butyl 3-(3-fluoro-4-((4-methylpiperazin-1-yl)methyl)phenoxy)azetidine-1-carboxylate

Product 1

HCID 666534801-(4-(Azetidin-3-yloxy)-2-fluorobenzyl)-4-methylpiperazine

Sources & evidence

ORD record
ord-981ad73dfd0f479386af7a006538d2db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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