Dichloromethane → 2-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

HRID 1575099Notes

Reaction equation

HRID 1575099 reaction equation
[CH3:25][CH2:26][N:27]([CH2:28][CH3:29])[CH2:30][CH3:31].[CH:32]1([S:35](=[O:36])(=[O:37])[Cl:38])[CH2:33][CH2:34]1.[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:18])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[s:10]2.[Cl:39][CH2:40][Cl:41]>>[Cl:1][c:2]1[n:3][c:4]([N:19]2[CH2:20][CH2:21][O:22][CH2:23][CH2:24]2)[c:5]2[c:6]([n:7]1)[c:8]([CH3:18])[c:9]([CH2:11][N:12]1[CH2:13][CH2:14][N:15]([S:35]([CH:32]3[CH2:33][CH2:34]3)(=[O:36])=[O:37])[CH2:16][CH2:17]1)[s:10]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 2760919Cyclopropanesulfonyl chlorideHCID 866235192-Chloro-7-methyl-4-morpholino-6-((piperazin-1-yl)methyl)thieno[3,2-d]pyrimidine

Product 1

HCID 866235342-Chloro-6-(4-cyclopropanesulfonyl-piperazin-1-ylmethyl)-7-methyl-4-morpholin-4-yl-thieno[3,2-d]pyrimidine

Sources & evidence

ORD record
ord-eb4b5259bde54c1593e5196b8e0a767b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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