Dichloromethane → methyl 4-(4-(5-amino-6-(1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)-5,6-dihydropyridin-1(2H)-yl)-4-oxobutanoate

HRID 1575302Notes

Reaction equation

HRID 1575302 reaction equation
[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[Cl:23][C:24]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH3:30])=[O:31].[Cl:39][CH2:40][Cl:41].[nH:1]1[c:2](-[c:10]2[c:11]([NH2:22])[n:12][cH:13][c:14]([C:16]3=[CH:21][CH2:20][NH:19][CH2:18][CH2:17]3)[n:15]2)[n:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2>>[n:1]1[c:2](-[c:10]2[c:11]([NH2:22])[n:12][cH:13][c:14]([C:16]3=[CH:21][CH2:20][N:19]([C:24]([CH2:25][CH2:26][C:27](=[O:28])[O:29][CH3:30])=[O:31])[CH2:18][CH2:17]3)[n:15]2)[nH:3][c:4]2[c:5]1[cH:6][cH:7][cH:8][cH:9]2

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 73888Butanoic acid, 4-chloro-4-oxo-, methyl esterHCID 667451703-(1H-benzo[d]imidazol-2-yl)-5-(1,2,3,6-tetrahydropyridin-4-yl)pyrazin-2-amine

Product 1

HCID 66745179methyl 4-(4-(5-amino-6-(1H-benzo[d]imidazol-2-yl)pyrazin-2-yl)-5,6-dihydropyridin-1(2H)-yl)-4-oxobutanoate

Sources & evidence

ORD record
ord-ca9fd0c9969a42f89d0ca95b155c3eb7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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