Sodium ion → [5-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

HRID 1575861Notes

Reaction equation

HRID 1575861 reaction equation
[Br:22][c:23]1[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]2[CH2:31][CH2:32][CH2:33][CH2:34]2)[cH:35][cH:36]1.[CH3:105][C:106]([N:107]([CH3:108])[CH3:109])=[O:110].[CH3:37][C:38]([CH3:39])([O-:40])[CH3:41].[Na+:42].[O:1]1[CH2:2][CH2:3][O:4][c:5]2[c:6]1[cH:7][cH:8][c:9](-[c:11]1[cH:12][c:13]([CH3:21])[cH:14][c:15]3[n:16]1[n:17][c:18]([NH2:20])[n:19]3)[cH:10]2.[O:43]1[CH2:44][CH2:45][O:46][CH2:47][CH2:48]1.[O:51]=[C:52]([CH:53]=[CH:54][c:55]1[cH:56][cH:57][cH:58][cH:59][cH:60]1)[CH:61]=[CH:62][c:63]1[cH:64][cH:65][cH:66][cH:67][cH:68]1.[O:69]=[C:70]([CH:71]=[CH:72][c:73]1[cH:74][cH:75][cH:76][cH:77][cH:78]1)[CH:79]=[CH:80][c:81]1[cH:82][cH:83][cH:84][cH:85][cH:86]1.[O:87]=[C:88]([CH:89]=[CH:90][c:91]1[cH:92][cH:93][cH:94][cH:95][cH:96]1)[CH:97]=[CH:98][c:99]1[cH:100][cH:101][cH:102][cH:103][cH:104]1.[Pd:49].[Pd:50]>>[O:1]1[CH2:2][CH2:3][O:4][c:5]2[c:6]1[cH:7][cH:8][c:9](-[c:11]1[cH:12][c:13]([CH3:21])[cH:14][c:15]3[n:16]1[n:17][c:18]([NH:20][c:23]1[cH:24][cH:25][c:26]([O:27][CH2:28][CH2:29][N:30]4[CH2:31][CH2:32][CH2:33][CH2:34]4)[cH:35][cH:36]1)[n:19]3)[cH:10]2

Participants

9

Reactant 8

HCID 923Sodium ionHCID 23938Palladium2×HCID 312751,4-DioxaneHCID 31374DimethylacetamideHCID 70657N-(2-(p-bromophenoxy)ethyl)pyrrolidineHCID 95417Dibenzylidene acetone3×HCID 45749132-Methylpropan-2-olateHCID 595895355-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine

Product 1

HCID 59589608[5-(2,3-Dihydro-benzo[1,4]dioxin-6-yl)-7-methyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine

Sources & evidence

ORD record
ord-45bec45cc7cc47e085dd3d0a22022b96
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Reaction notes

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