HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl (ethoxymethylene)malonate → [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl (ethoxymethylene)malonate | HCID 6871 | — |
| Reactant | 1-(furan-2-ylmethyl)-1H-pyrazol-5-amine | HCID 2546182 | — |
| Product | [[[1-(2-Furyl)methyl-5-pyrazolyl]amino]methylene]malonic acid diethyl ester | HCID 68131587 | — |
Reaction Steps
163 g of 1-(2-furyl)methyl-5-aminopyrazole (1mol) and 216 g of ethoxymethylene malonic acid diethyl ester (1 mol) are heated to 130° (bath temperature) until the theoretical amount of alcohol is distilled off. The remaining oil, [[[1-(2-furyl)methyl-5-pyrazolyl]aino]methylene]malonic acid diethyl ester, is recrystallized from methanol, yield 280 g (84%), m.p. 84°-86°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03979399 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-b26c8060166c4543bb060eb89364f663 |
| Source note | uspto-grants-1976_09 |