1-Methylpiperazine → 1,2,4-Triazine, 5,6-bis(4-methoxyphenyl)-3-(4-methyl-1-piperazinyl)-

HRID 1576237Notes

Reaction equation

HRID 1576237 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11](SC)[N:12]=[N:13][C:14]=2[C:15]2[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=2)=[CH:5][CH:4]=1.[CH3:25][N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>O>[CH3:25][N:26]1[CH2:31][CH2:30][N:29]([C:11]2[N:12]=[N:13][C:14]([C:15]3[CH:20]=[CH:19][C:18]([O:21][CH3:22])=[CH:17][CH:16]=3)=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][CH:5]=3)[N:10]=2)[CH2:28][CH2:27]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 6172401,2,4-Triazine, 5,6-bis(4-methoxyphenyl)-3-(methylthio)-

Product 1

HCID 30423861,2,4-Triazine, 5,6-bis(4-methoxyphenyl)-3-(4-methyl-1-piperazinyl)-

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Ten grams of 5,6-bis(4-methoxyphenyl)-3-methylthio-1,2,4-triazine and 40 ml. of N-methylpiperazine were refluxed for 12 hours. The reaction mixture was poured into water and the solid product was collected. The product was crystallized twice from 75 ml. of ethanol and twice from ethyl acetate to yield 1.8 g. of 3-(4-methylpiperazino)-5,6-bis(4-me;thoxyphenyl)-1,2,4-triazine, mp about 158°-160°C.

Workup

  1. customthe solid product was collected
  2. customThe product was crystallized twice from 75 ml
  3. customof ethanol and twice from ethyl acetate to yield 1.8 g

Sources & evidence

ORD record
ord-2df90fefbdf4405a9553b52754072f6d
Source dataset
uspto-grants-1976_09
Patent number
US03979516

Reaction notes

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