Ammonium Hydroxide → HCID 86733951, compound

HRID 1576264Notes

Reaction equation

HRID 1576264 reaction equation
[CH3:1][O:2][C:3]1[CH:11]=[CH:10][CH:9]=[C:8]([CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=2)[C:4]=1[C:5](O)=O.[OH-:23].[NH4+]>>[CH3:1][O:2][C:3]1([OH:23])[C:4]2[C:8](=[CH:12][C:13]3[C:18]([CH:5]=2)=[CH:17][CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[CH:14]=3)[CH:9]=[CH:10][CH2:11]1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 21514899HCID 21514899, compound

Product 1

HCID 86733951HCID 86733951, compound

Procedure

2-Methoxy-6-(3'-trifluoromethylbenzyl)benzoic acid (3.1 g.) is added in small portions with stirring to polyphosphoric acid (60 ml.) at 90°-95°C., the reaction mixture is stirred for 30 minutes at this temperature and then allowed to cool. Excess 8N ammonium hydroxide solution is added and the solution is stirred for 15 minutes and then extracted with ether. The ether layer is washed with water and with brine, and evaporated to give 1-methoxy-6-trifluoromethylanthrol, m.p. 102°-110°C., which is used without further purification.

Workup

  1. temperatureto cool
  2. stirringthe solution is stirred for 15 minutes
  3. extractionextracted with ether
  4. washThe ether layer is washed with water and with brine
  5. customevaporated

Sources & evidence

ORD record
ord-4e1674df676c45b19a0423e3f93d200b
Source dataset
uspto-grants-1976_09
Patent number
US03979513

Reaction notes

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