HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 1-Methyl-3-phenylpyrimidine-2,4,6(1H,3H,5H)-trione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | N-Methyl-N-phenylurea | HCID 78316 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1-Methyl-3-phenylpyrimidine-2,4,6(1H,3H,5H)-trione | HCID 15545494 | — |
Reaction Steps
1-Phenyl-3-methyl-barbituric acid was prepared by condensation of malonic acid diethyl ester with phenyl-methylurea in methanol, with addition of sodium methylate. It melts at about 124°C after recrystallization from toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03980651 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-fbfdc7f682864a818a9f55326ba07baa |
| Source note | uspto-grants-1976_09 |