反应详情

A mixture of 3.0 g. of 4-[2-(ethylamino)ethyl]-pyridine and 2.0 g. of triethylamine in 60 ml. of dry chloroform is treated at 0°C. with a solution of 2.1 g. of carboethoxy chloride in 10 ml. of dry chloroform. After stirring for two hours, the mixture is poured into ice water and 5 percent aqueous sodium hydroxide added. The chloroform layer is separated, washed with water and dried over potassium carbonate. The solvent is evaporated and the residue distilled in vacuo to give 4-[2-(N-carboethoxy-N-ethylamino)ethyl]pyridine.

1. additionA mixture of 3.0 g
2. additionadded
3. customThe chloroform layer is separated
4. washwashed with water
5. dry with materialdried over potassium carbonate
6. customThe solvent is evaporated
7. distillationthe residue distilled in vacuo