Acetic Anhydride → HCID 21512582, compound

HRID 1576400Notes

Reaction equation

HRID 1576400 reaction equation
[CH:1]1[C:14]2[CH:13]([N:15]3[CH2:20][CH2:19][CH2:18][CH:17]([NH:21][CH3:22])[CH2:16]3)[C:12]3[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=3)[O:6][C:5]=2[CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.[C:30](OC(=O)C)(=[O:32])[CH3:31]>C(Cl)(Cl)Cl>[CH:11]1[C:12]2[CH:13]([N:15]3[CH2:20][CH2:19][CH2:18][CH:17]([N:21]([C:30](=[O:32])[CH3:31])[CH3:22])[CH2:16]3)[C:14]3[C:5](=[CH:4][CH:3]=[CH:2][CH:1]=3)[O:6][C:7]=2[CH:8]=[CH:9][CH:10]=1

Participants

5

Reactant 3

HCID 7918Acetic AnhydrideHCID 8471TriethylamineHCID 21512538HCID 21512538, compound

Product 1

HCID 21512582HCID 21512582, compound

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent2×

Procedure

A mixture of 1.0 g. of 1-(9-xanthenyl)-3-methylaminopiperidine and 2.0 g. of triethylamine in 25 ml. of dry chloroform is treated at 0°C. with 0.5 g. of acetic anhydride in 2 ml. of dry chloroform. The mixture is refluxed with stirring for two hours and then poured into ice water. The chloroform layer is washed with water, dried over potassium carbonate, and the solvent is removed in vacuo to give 1-(9-xanthenyl)-3-(N-acetyl-N-methylamino)-piperidine.

Workup

  1. additionA mixture of 1.0 g
  2. temperatureThe mixture is refluxed
  3. washThe chloroform layer is washed with water
  4. dry with materialdried over potassium carbonate
  5. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-ecfaaf45bd3541a68c3c5dcb5f1dd549
Source dataset
uspto-grants-1976_09
Patent number
US03980788

Reaction notes

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