反应详情

A solution of 30.2 g of 3-p-iodophenyl-3-methyl-pyrazolidin-5-one (obtainable from p-iodoacetophenone via 3-hydroxy-3-p-iodophenyl-butyric acid ethyl ester and 3-p-iodophenyl-2-butenoic acid ethyl ester) and 13.4 g of sodium p-fluorophenolate in 200 ml of DMF is warmed for 8 hours at 130°. Working up in the usual manner gives 3-(4'-fluoro-4-biphenylyl)-3-methyl-pyrazolidin-5-one, m.p. 194°-196°.