Sulfuric Acid → HCID 21511444, compound

HRID 1576581Notes

Reaction equation

HRID 1576581 reaction equation
[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH:13]([CH3:19])[C:14](OCC)=[O:15])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-].[H-].S(=O)(=O)(O)O>CCOCC>[F:1][C:2]1[CH:21]=[CH:20][C:5]([O:6][C:7]2[CH:12]=[CH:11][C:10]([CH:13]([CH3:19])[CH2:14][OH:15])=[CH:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

6

Reactant 4

HCID 1118Sulfuric AcidHCID 166653HydrideHCID 21226445Aluminium lithium hydrideHCID 21511439HCID 21511439, compound

Product 1

HCID 21511444HCID 21511444, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

Ethyl 2-[4-(4-fluorophenoxy)phenyl]propionate (1.3 g.) in dry ether (5 ml.) was added dropwise to lithium aluminium hydride (200 mg.) in dry ether (5 ml.). After refluxing for 1 hour the excess hydride was decomposed with dilute sulfuric acid, and the ether layer was distilled to give 2-[4-(4-fluorophenoxy)phenyl]propanol, b.p. 151°-152°C./0.6 mm.

Workup

  1. distillationthe ether layer was distilled

Sources & evidence

ORD record
ord-16373e5b8c2e42a092af6b67a631f7b0
Source dataset
uspto-grants-1976_09
Patent number
US03981905

Reaction notes

Loading…