HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isovincamine → Vincamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isovincamine | HCID 5668 | — |
| Reactant | Tetrabutylammonium Hydroxide | HCID 2723671 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Vincamine | HCID 15376 | 36% |
Reaction Steps
If the isomerisation of 16-epivincamine described in Example 4 is repeated but using 177 mg. (0.5 millimole) of 16-epivincamine in 20 ml. of methanol and 130 mg. (0.2 millimole) of a 40% aqueous solution of tetrabutylammonium hydroxide (formula (I)b), and the mixture is allowed to stand for 5 hours at 25°C. 64 mg. of vincamine are obtained (yield 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03982002 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-9012b34a41504efb94d4b4cd7605aaec |
| Source note | uspto-grants-1976_09 |