Ammonia → HCID 21511621, compound

HRID 1576676Notes

Reaction equation

HRID 1576676 reaction equation
[O:1]1[CH:3]([CH2:4][O:5][C:6]2[S:7][CH:8]=[CH:9][N:10]=2)[CH2:2]1.[NH3:11]>C(O)C>[NH2:11][CH:2]([OH:1])[CH2:3][CH2:4][O:5][C:6]1[S:7][CH:8]=[CH:9][N:10]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 12399817HCID 12399817, compound

Product 1

HCID 21511621HCID 21511621, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

This example illustrates methods according to the invention of converting the compounds of formula II, of the invention, into the compounds of formula I of the invention. In this example, 300 mg. of 1,2-epoxy-3-(thiazol-2-oxy)-propane is dissolved in 5 ml. of ethanol saturated with ammonia and left at room temperature for 20 hours. The reaction mixture is then evaporated to remove all residual solvent, and the residue is purified by thin-layer chromatography on preparative silica plate using a developing system of 1 percent triethylamine, 1.5 percent methanol and the remainder ethyl acetate to yield 1-amino-3-(thiazol-2-oxy)-propanol.

Workup

  1. customThe reaction mixture is then evaporated
  2. customto remove all residual solvent
  3. customthe residue is purified by thin-layer chromatography on preparative silica plate

Sources & evidence

ORD record
ord-5052aff76ceb4ed6a572cbe292e6b7b0
Source dataset
uspto-grants-1976_09
Patent number
US03982010

Reaction notes

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