Ammonia → HCID 21511621, compound

Participants

Reaction Steps

This example illustrates methods according to the invention of converting the compounds of formula II, of the invention, into the compounds of formula I of the invention. In this example, 300 mg. of 1,2-epoxy-3-(thiazol-2-oxy)-propane is dissolved in 5 ml. of ethanol saturated with ammonia and left at room temperature for 20 hours. The reaction mixture is then evaporated to remove all residual solvent, and the residue is purified by thin-layer chromatography on preparative silica plate using a developing system of 1 percent triethylamine, 1.5 percent methanol and the remainder ethyl acetate to yield 1-amino-3-(thiazol-2-oxy)-propanol.

Provenance & Evidence