Hydrochloric Acid → 1-[(Propan-2-yl)amino]-3-[(1,3-thiazol-2-yl)oxy]propan-2-ol--hydrogen chloride (1/1)

HRID 1576680Notes

Reaction equation

HRID 1576680 reaction equation
[ClH:1].[CH:2]([NH:5][CH2:6][CH:7]([OH:15])[CH2:8][O:9][C:10]1[S:11][CH:12]=[CH:13][N:14]=1)([CH3:4])[CH3:3]>C(OCC)C>[ClH:1].[CH:2]([NH:5][CH2:6][CH:7]([OH:15])[CH2:8][O:9][C:10]1[S:11][CH:12]=[CH:13][N:14]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric Acid2×HCID 717211-[(Propan-2-yl)amino]-3-[(1,3-thiazol-2-yl)oxy]propan-2-ol

Product 1

HCID 717201-[(Propan-2-yl)amino]-3-[(1,3-thiazol-2-yl)oxy]propan-2-ol--hydrogen chloride (1/1)

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

This example illustrates methods of preparing hydrochloride addition salts of the invention. In this example 1 g. of 1-isopropylamino-3-(thiazol-2-oxy)-2-propanol is dissolved in 10 ml. of ethyl ether at 20°C. A stream of gaseous anhydrous hydrogen chloride is passed over the surface of the solution until the supernatent liquid becomes colorless. The resulting precipitate is collected by filtration, washed with ethyl ether and then crystallized from methanol, containing 1% water and 1% acetone, affording crystalline 1-isopropylamino-3-(thiazol-2-oxy)-2-propanol hydrochloride.

Workup

  1. customat 20°C
  2. filtrationThe resulting precipitate is collected by filtration
  3. washwashed with ethyl ether
  4. customcrystallized from methanol
  5. additioncontaining 1% water and 1% acetone

Sources & evidence

ORD record
ord-74f53b035f3646379b0ebe69416482e2
Source dataset
uspto-grants-1976_09
Patent number
US03982010

Reaction notes

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