HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazole → cis-4,6-Diethyl-5-(4-fluorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazole | HCID 1048 | — |
| Reactant | 4-Fluorobenzenesulfonyl chloride | HCID 9588 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | cis-7,9-Diethyl-1,4-dioxa-8-azaspiro[4.5]decane | HCID 59342374 | — |
| Reactant | 2,6-Diethyl-1-(4-fluorophenylsulfonyl)piperidin-4-one | HCID 68501988 | — |
| Product | cis-4,6-Diethyl-5-(4-fluorophenylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine | HCID 68499313 | — |
Reaction Steps
Prepared by treatment of 2,6-diethyl-1-(4-fluorophenylsulfonyl)piperidin-4-one, which was prepared by sulfonylation of compound 126 using 4-fluorobenzenesulfonyl chloride followed by deprotection as shown in Example 17, with DMF-DMA followed by pyrazole formation using hydrazine hydrate as shown in Example 15.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732609B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-2b900573df6e4375b11784a30c453654 |
| Source note | uspto-grants-2010_06 |