Acetonitrile → N-(trans-4-Trifluoromethyl-cyclohexyl)-2-(2-difluoromethoxy-ethoxy)-6-amino-5-nitro-nicotinamide
Reaction equation
[CH3:38][C:39]#[N:40].[Cu:41][I:42].[F:11][C:12]([CH:13]1[CH2:14][CH2:15][CH:16]([NH:19][C:20]([c:21]2[c:22]([O:31][CH2:32][CH2:33][OH:34])[n:23][c:24]([NH2:30])[c:25]([N+:27](=[O:28])[O-:29])[cH:26]2)=[O:35])[CH2:17][CH2:18]1)([F:36])[F:37].[F:1][C:2]([S:3]([F:4])(=[O:5])=[O:6])([C:7]([OH:8])=[O:9])[F:10]>>[F:1][CH:2]([F:10])[O:34][CH2:33][CH2:32][O:31][c:22]1[c:21]([C:20]([NH:19][CH:16]2[CH2:15][CH2:14][CH:13]([C:12]([F:11])([F:36])[F:37])[CH2:18][CH2:17]2)=[O:35])[cH:26][c:25]([N+:27](=[O:28])[O-:29])[c:24]([NH2:30])[n:23]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-6c977247d52a4d3ab78bd99773e7c168
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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