Hydrochloric Acid → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

HRID 1576777Notes

Reaction equation

HRID 1576777 reaction equation
[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:19][CH2:18][O:17][CH2:16][CH2:15]2)[CH2:3]1.[ClH:31]>C(O)C>[ClH:31].[OH:1][C@@H:2]1[CH2:27][CH2:26][C@@:25]2([CH3:28])[C@@H:4]([CH2:5][CH2:6][C@@H:7]3[C@@H:24]2[C:23](=[O:29])[CH2:22][C@@:21]2([CH3:30])[C@H:8]3[CH2:9][CH2:10][C@@H:11]2[C:12](=[O:20])[CH2:13][N:14]2[CH2:15][CH2:16][O:17][CH2:18][CH2:19]2)[CH2:3]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 867340213alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione

Product 1

HCID 867340253alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (104.14 mg., 0.25 mmole) in ethanol (4 ml.) was treated with 0.1N hydrochloric acid (2.5 ml., 0.25 mmole). The solution was evaporated in vacuo and then treated with water (5 ml.). The undissolved solid (8.4 mg.) was removed by filtration and the filtrate was made up to 9.6 ml. with distilled water to give a 1% aqueous solution of the title compound.

Workup

  1. customThe solution was evaporated in vacuo
  2. additiontreated with water (5 ml.)
  3. customThe undissolved solid (8.4 mg.) was removed by filtration

Sources & evidence

ORD record
ord-740cbae19b3341ea8e4cd3ca7830c7af
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

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