Methanesulfonic Acid → 3alpha-Hydroxy-21-morpholino-5alpha-pregnane-11,20-dione mesylate

Participants

Reaction Steps

A solution of 3α-hydroxy-21-morpholino-5α-pregnane-11,20dione (167 mg., 0.4 mmole) in ethanol (2 ml.) was treated with 0.204 N aqueous solution of methanesulphonic acid (3.92 ml. 0.8 mmole). The resulting solution was evaporated under vacuum and then treated with water (5 ml.). The undissolved solid (14.7 mg.) was removed by filtration and the filtrate was made up to 15.23 ml. with distilled water thereby obtaining a 1% aqueous solution of the title compound.

Provenance & Evidence