L-Ascorbic Acid → 2beta-Ethoxy-3alpha-hydroxy-21-morpholino-5alpha-pregnane-11,20-dione ascorbate

Participants

Reaction Steps

A solution of 2β-Ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (116 mg; 0.25 mmole) in ethanol (2 ml.) was treated with an 0.1N aqueous solution of ascorbic acid (2.5 ml; 0.25 mmole) and the resulting solution was evaporated under vacuum. The residue was dissolved in water (ca. 5 ml.) and clarified by filtration. The filtrate was diluted to 11.6 ml. with distilled water, thereby giving a 1% aqueous solution of the title compound.

Provenance & Evidence