Citric Acid → HCID 86734022, compound

HRID 1576786Notes

Reaction equation

HRID 1576786 reaction equation
[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2].[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37]>C(O)C>[C:34]([OH:46])(=[O:45])[CH2:35][C:36]([CH2:41][C:42]([OH:44])=[O:43])([C:38]([OH:40])=[O:39])[OH:37].[CH2:1]([O:3][C@H:4]1[CH2:29][C@@:28]2([CH3:30])[C@@H:7]([CH2:8][CH2:9][C@@H:10]3[C@@H:27]2[C:26](=[O:31])[CH2:25][C@@:24]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C:15](=[O:23])[CH2:16][N:17]2[CH2:22][CH2:21][O:20][CH2:19][CH2:18]2)[CH2:6][C@@H:5]1[OH:33])[CH3:2]

Participants

4

Reactant 2

HCID 311Citric AcidHCID 86734023HCID 86734023, compound

Product 1

HCID 86734022HCID 86734022, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (0.93 g.) in ethanol (1 ml.) was treated with a 0.1 M solution of citric acid (20 ml.) at room temperature. The solution was evaporated to dryness and redissolved in distilled water (5 ml.). The resulting solution was filtered and the collected residue was washed with water (1 ml.). The filtrate and washings were made up to 9.2 ml with distilled water thereby giving a solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione citrate at concentration 100 mg./ml. with respect to steroid (pH 3.5).

Workup

  1. customThe solution was evaporated to dryness
  2. dissolutionredissolved in distilled water (5 ml.)
  3. filtrationThe resulting solution was filtered
  4. washthe collected residue was washed with water (1 ml.)

Sources & evidence

ORD record
ord-eb21d54d283449a59487cd40719d516f
Source dataset
uspto-grants-1976_09
Patent number
US03983111

Reaction notes

Loading…