Citric Acid → HCID 86734022, compound

Participants

Reaction Steps

A solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione (0.93 g.) in ethanol (1 ml.) was treated with a 0.1 M solution of citric acid (20 ml.) at room temperature. The solution was evaporated to dryness and redissolved in distilled water (5 ml.). The resulting solution was filtered and the collected residue was washed with water (1 ml.). The filtrate and washings were made up to 9.2 ml with distilled water thereby giving a solution of 2β-ethoxy-3α-hydroxy-21-morpholino-5α-pregnane-11,20-dione citrate at concentration 100 mg./ml. with respect to steroid (pH 3.5).

Provenance & Evidence