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HRID1576792

反应详情

EQUATION

反应方程式

HRID 1576792 的结构方程式

REACTANTS

反应物

4
结构：O
HCID962

Water

H2O

结构：CC(=O)Cl
HCID6367

Acetyl chloride

C2H3ClO

结构：BrBr
HCID24408

Bromine

Br2

结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O
HCID86733287

未命名化合物

PRODUCTS

生成物

1
结构：CCO[C@H]1C[C@@]2(C)[C@@H](CC[C@H]3[C@@H]4CC[C@H](C(=O)CBr)[C@@]4(C)CC(=O)[C@@H]32)C[C@@H]1O
HCID121291880

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CO
溶剂HCID887

Methanol

CH4O

2 次

PROCEDURE

实验过程

Bromine (0.53 g.) in methanol (1.45 ml.) was added dropwise to a stirred solution of 3α-hydroxy-2β-ethoxy-5α-pregnane-11,20-dione (2.0 g) in methanol (15 ml) containing a trace of acetyl chloride at 0°. The addition took 2 hr. and the clear solution was then poured into water and collected by filtration, washed with water and dried in vacuo to give title compound.

WORKUP

后处理

  1. additionThe addition
  2. filtrationcollected by filtration
  3. washwashed with water
  4. customdried in vacuo