Hydrogen Bromide → HCID 178510527, compound

Participants

Reaction Steps

A mixture of 20 g of 3-methoxy-4-cyano-5-phenyl-isothiazole [prepared by the method of U.S. Pat. No. 3,476,765] and 200 ml of a solution of 25 parts by weight of hydrobromic acid in 75 parts by weight of acetic acid was heated at 80°C with stirring for 1 hour and the resulting suspension was evaporated to dryness under reduced pressure. The residue was empasted with ethanol and the mixture was vacuum filtered to obtain 16 g of 3-hydroxy-4-cyano-5-phenyl-isothiazole in the form of white crystals melting at 234°C.

Provenance & Evidence