Hydrogen Bromide → HCID 178510527, compound

HRID 1576806Notes

Reaction equation

HRID 1576806 reaction equation
C[O:2][C:3]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[S:5][N:4]=1.Br>C(O)(=O)C>[OH:2][C:3]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=2)[S:5][N:4]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 5129613-Methoxy-5-phenylisothiazole-4-carbonitrile

Product 1

HCID 178510527HCID 178510527, compoundYield 85.5%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A mixture of 20 g of 3-methoxy-4-cyano-5-phenyl-isothiazole [prepared by the method of U.S. Pat. No. 3,476,765] and 200 ml of a solution of 25 parts by weight of hydrobromic acid in 75 parts by weight of acetic acid was heated at 80°C with stirring for 1 hour and the resulting suspension was evaporated to dryness under reduced pressure. The residue was empasted with ethanol and the mixture was vacuum filtered to obtain 16 g of 3-hydroxy-4-cyano-5-phenyl-isothiazole in the form of white crystals melting at 234°C.

Workup

  1. customprepared by the method of U.S
  2. customthe resulting suspension was evaporated to dryness under reduced pressure
  3. filtrationfiltered

Sources & evidence

ORD record
ord-237ed8c1d4994b0fb920b78775d2253c
Source dataset
uspto-grants-1976_09
Patent number
US03983129

Reaction notes

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