反应详情

温度

150 °C

2,6-Dimethylaniline (60 grams), the dimethyl acetal of 2-chloroacetaldehyde (25 grams) and sodium carbonate (25 grams) were charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The mixture was heated at a temperature of about 150°C for a period of about 30 hours. After this time the reaction mixture was cooled to room temperature and was filtered. The filtrate was then distilled under vacuum to yield the desired product the dimethyl acetal of 2-(2,6-dimethylanilino)acetaldehyde as the residue having a boiling point of 105°C at 1.0 mm of Hg pressure.

1. customequipped with a mechanical stirrer
2. temperaturethermometer and reflux condenser
3. temperatureAfter this time the reaction mixture was cooled to room temperature
4. filtrationwas filtered
5. distillationThe filtrate was then distilled under vacuum