反应详情

2 g of 2-amino-4,5-dicyanoimidazole was dissolved in 20 ml of suspension of acetone containing 1.3 g of sodium bicarbonate and then 2.1 g of n-butyl chloroformate was added dropwise to said solution at a room temperature. The resulting solution was refluxed during 30 minutes, and white crystal was separated out when the rection mixture was poured into ice-water. After recrystallizing the crude product from methanol, 2.7 g of the purified compound having a melting point of 170° to 172°C was obtained as needles (Yield rate: 77%).

1. customat a room temperature
2. temperatureThe resulting solution was refluxed during 30 minutes
3. customwhite crystal was separated out when the rection mixture
4. additionwas poured into ice-water
5. customAfter recrystallizing the crude product from methanol, 2.7 g of the purified compound
6. customwas obtained as needles (Yield rate: 77%)