Water → 1,1'-(9H-Fluorene-2,7-diyl)bis(4-(1-piperidinyl)-1-butanone)

Participants

Reaction Steps

A mixture of 18.8 g (0.05 mole) of 2,7-bis(4-chlorobutyryl)fluorene, 34.0 g (0.4 mole) of piperidine, and 16.6 g (0.1 mole) of potassium iodide in 200 ml of butanone is stirred and refluxed for 3 days. The reaction mixture is poured into 1000 ml of water, and the solid which precipitates is filtered and recrystallized twice from chloroform-acetone to give the desired 2,7-bis(4-piperidinobutyryl)fluorene as the free base.

Provenance & Evidence