反应详情

温度

85 °C

59 g. of sodium amide (50% suspension in benzene) are placed in 1 liter of 1,2-dimethoxyethane and treated dropwise, while cooling with ice, with 109.2 g. of 1,1-dimethoxy-3,7-dimethyl-7-octanol in 400 ml. of 1,2-dimethoxyethane. The mixture is left to stir under a nitrogen atmosphere for 15 hours at 85°C. The mixture is then again cooled and treated dropwise with a solution of 89.3 g. of propargyl bromide in 250 ml. of 1,2-dimethoxyethane. The mixture is then left to stir at 40°C. until the reaction is complete. The mixture is poured on to 4 liters of ice-water and extracted twice with 2.5 liters of ether. The extracts are washed with 10% sodium hydroxide, water and saturated sodium chloride solution, dried over sodium sulphate and evaporated. By distillation or chromatography, there is obtained pure dimethylacetal of 3,7-dimethyl-(2-propynyloxy)-octanal; boiling point (bulb-tube) = 70°C/0.03 mmHg; nD25 = 1.4491. 65 g. of the dimethylacetal of 3,7-dimethyl-7-(2-propynyloxy)-octanal are heated at 40°C. for 16 hours with a mixture of 300 ml. of 2-N hydrochloric acid, 700 ml. of water and 1 liter of tetrahydrofuran while stirring well. For the working up, the mixture is poured on to 1 liter of ice-water and extracted twice with 1.5 liters of ether. The extracts are washed with 10% sodium carbonate solution, water and saturated sodium chloride solution, dried over sodium sulphate and evaporated. By distillation, there is obtained pure 3,7-dimethyl-7-(2-propynyloxy)-octanal; boiling point = 113°C/1 mmHg; nD25 = 1.4553.

1. additiontreated dropwise
2. temperaturewhile cooling with ice, with 109.2 g
3. waitThe mixture is left
4. temperatureThe mixture is then again cooled
5. additiontreated dropwise with a solution of 89.3 g
6. waitThe mixture is then left
7. stirringto stir at 40°C. until the reaction
8. extractionextracted twice with 2.5 liters of ether
9. washThe extracts are washed with 10% sodium hydroxide, water and saturated sodium chloride solution
10. dry with materialdried over sodium sulphate
11. customevaporated
12. distillationBy distillation or chromatography