Tetrafluoroboric acid → HCID 10241582, compound

HRID 1577007Notes

Reaction equation

HRID 1577007 reaction equation
[H+].[B-](F)(F)(F)F.Cl.[CH3:8][C:9]1[CH:17]=[CH:16][C:15]2[NH:14][C:13]3[CH2:18][CH2:19][NH:20][CH2:21][C:12]=3[C:11]=2[CH:10]=1>[Pt](=O)=O.O>[CH3:8][C:9]1[CH:17]=[CH:16][C:15]2[NH:14][CH:13]3[CH2:18][CH2:19][NH:20][CH2:21][CH:12]3[C:11]=2[CH:10]=1

Participants

5

Reactant 2

HCID 28118Tetrafluoroboric acidHCID 215104198-Methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride

Product 1

HCID 10241582HCID 10241582, compoundYield 87.2%

Reagents, catalysts & solvents 2

HCID 345198Adams' catalystCatalystHCID 962WaterSolvent

Procedure

To a mixture of water (50 ml) and 42 % borofluoric acid (18 ml) is added 8-methyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole hydrochloride (5.7 g), and the mixture is subjected to a catalytic reduction under heating in the presence of platinum dioxide (0.2 g). When hydrogen (820 ml) is absorbed, the catalyst is filtered off and the filtrate is made alkaline with aqueous ammonia, salted out with potassium carbonate and extracted with benzene. The benzene layer is washed with water, dried over anhydrous sodium sulfate and concentrated to give the titled compound (4.2 g), m.p. 73° - 75°C.

Workup

  1. customWhen hydrogen (820 ml) is absorbed
  2. filtrationthe catalyst is filtered off
  3. extractionextracted with benzene
  4. washThe benzene layer is washed with water
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated

Sources & evidence

ORD record
ord-e6ffadfc42fb4a4b8de39e8dfae8954f
Source dataset
uspto-grants-1976_09
Patent number
US03983239

Reaction notes

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