Phenacyl bromide → HCID 21435299, compound

HRID 1577030Notes

Reaction equation

HRID 1577030 reaction equation
[CH2:1]([C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[CH:6][CH:5]=1)[CH2:2][CH3:3].[F:11][C:12]([F:21])([F:20])[C:13]1[CH:18]=[CH:17][C:16]([OH:19])=[CH:15][CH:14]=1.Br[CH2:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=O>>[C:26]1([C:24]2[C:6]3[CH:5]=[C:4]([CH2:1][CH2:2][CH3:3])[CH:9]=[CH:8][C:7]=3[O:10][CH:23]=2)[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1.[C:4]1([C:1]2[C:17]3[CH:18]=[C:13]([C:12]([F:20])([F:21])[F:11])[CH:14]=[CH:15][C:16]=3[O:19][CH:2]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 6259Phenacyl bromideHCID 125804-PropylphenolHCID 678744-(Trifluoromethyl)phenol

Product 2

HCID 21435299HCID 21435299, compoundHCID 21510500HCID 21510500, compound

Procedure

When 4-n-propylphenol or 4-trifluoromethylphenol is reacted with α-bromoacetophenone according to the procedure described in Example 14 and the resulting product is cyclized by heating with polyphosphoric acid at 80° as described therein, 3-phenyl-5-n-propylbenzofuran and 3-phenyl-5-trifluoromethylbenzofuran are obtained.

Sources & evidence

ORD record
ord-627c8f42df41435186875b1282d295ec
Source dataset
uspto-grants-1976_09
Patent number
US03983245

Reaction notes

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