2-Methoxyethanol → Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

HRID 1577071Notes

Reaction equation

HRID 1577071 reaction equation
Cl.Cl[CH2:3][CH2:4][N:5]([CH2:9][CH2:10]Cl)[CH2:6][CH2:7]Cl.[CH3:12][O:13][CH2:14][CH2:15][OH:16]>>[CH2:4]([N:5]([CH2:9][CH2:10][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:6][CH2:7][O:16][CH2:15][CH2:14][O:13][CH3:12])[CH2:3][O:16][CH2:15][CH2:14][O:13][CH3:12]

Participants

3

Reactant 2

HCID 80192-MethoxyethanolHCID 61220Tris(2-chloroethyl)amine hydrochloride

Product 1

HCID 112414Ethanamine, 2-(2-methoxyethoxy)-N,N-bis[2-(2-methoxyethoxy)ethyl]-

Procedure

51.6 g (namely, 0.215 mol) of tris-(2-chloroethyl)-amine hydrochloride were added to the above mixture. The mixture was subsequently heated at the reflux temperature of the 2-methoxyethanol (125° C.) for 12 hours and the solvent was then distilled under reduced pressure. The excess sodium 2-methoxyethanolate was neutralized by adding 11.6 cm3 of aqueous HCl (10 N). The sodium chloride was filtered off and the solution was distilled.

Workup

  1. distillationthe solvent was then distilled under reduced pressure
  2. additionby adding 11.6 cm3 of aqueous HCl (10 N)
  3. filtrationThe sodium chloride was filtered off
  4. distillationthe solution was distilled

Sources & evidence

ORD record
ord-af468309fbbb4460a9d40217fa30154c
Source dataset
uspto-grants-1981_09
Patent number
US04287125

Reaction notes

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