反应详情

(S)-1,5,10,10a-Tetrahydrothiazolo[3,4-b]-isoquinoline-3-thione (8.8 g) is dissolved in methylene chloride (100 cc), and benzyl iodide (9.5 g) is added. After 48 hours at a temperature of about 20° C., diisopropyl ether (200 cc) is added. The resulting precipitate is filtered off, washed with diisopropyl ether and dried at 20° C. under reduced pressure (1 mm Hg; 0.13 kPa). (S)-3-Benzylthio-1,5,10,10a-tetrahydrothiazolo[3,4-b]isoquinolinium iodide (15.6 g) is thus obtained.

1. filtrationThe resulting precipitate is filtered off
2. washwashed with diisopropyl ether
3. customdried at 20° C. under reduced pressure (1 mm Hg; 0.13 kPa)