反应详情

A mixture of 6 parts of methyl N-(2,2-dimethoxyethyl)-N'-[4-(4-methoxyphenyl)-1-piperazinyl]carbamimidothioate monohydroiodide and 30 parts of a hydrochloric acid solution 6 N is stirred and refluxed for 1 hour. The reaction mixture is cooled and adjusted to pH 10 with sodium hydroxide solution. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone, yielding 3.7 parts (100%) of 1-(4-methoxyphenyl)-4-[2-(methylthio)-1H-imidazol-1-yl]piperazine, mp. 140.1° C.

1. temperaturerefluxed for 1 hour
2. temperatureThe reaction mixture is cooled
3. filtrationThe precipitated product is filtered off
4. customcrystallized from 4-methyl-2-pentanone