反应详情

A mixture of 4 parts of 4-[4-(4,5-dihydro-5-methoxy-2-thiazolyl)-1-piperazinyl]phenol and 150 parts of a hydrobromic acid solution 48% is stirred and refluxed for 12 hours. The reaction mixture is evaporated and the residue is dissolved in water. The precipitated product is filtered off and crystallized from 4-methyl-2-pentanone. The product is filtered off and dried, yielding 2.5 parts (68%) of 4-[4-(2-thiazolyl)-1-piperazinyl]phenol; mp. 169.9° C.

1. temperaturerefluxed for 12 hours
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved in water
4. filtrationThe precipitated product is filtered off
5. customcrystallized from 4-methyl-2-pentanone
6. filtrationThe product is filtered off
7. customdried