反应详情

A mixture of 3.1 parts of 1-(1H-imidazol-1-yl)-4-(4-methoxyphenyl)piperazine and 150 parts of a hydrobromic acid solution 48% in glacial acetic acid is stirred and refluxed overnight. The reaction mixture is evaporated and the residue is dissolved in water. Upon the addition of an excess of sodium hydrogen carbonate, the product is crystallized. It is filtered off and crystallized again from a mixture of N,N-dimethylformamide and water, yielding 2.8 parts (95%) of 4-[4-(1H-imidazol-1-yl)-1-piperazinyl]phenol; mp. 282.4° C.

1. temperaturerefluxed overnight
2. customThe reaction mixture is evaporated
3. dissolutionthe residue is dissolved in water
4. additionUpon the addition of an excess of sodium hydrogen carbonate
5. customthe product is crystallized
6. filtrationIt is filtered off
7. customcrystallized again from a mixture of N,N-dimethylformamide and water