Dimethylformamide → N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

HRID 1577236Notes

Reaction equation

HRID 1577236 reaction equation
[N:1]#[C:2][NH2:3].[Pb].[CH3:5][NH:6][C:7]([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][N:15]=1)=S.CN(C)C=O>C(#N)C>[C:2]([NH:3][C:7]([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]1[CH:18]=[CH:17][S:16][N:15]=1)=[N:6][CH3:5])#[N:1]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 20466672N-Methyl-N'-(2-{[(1,2-thiazol-3-yl)methyl]sulfanyl}ethyl)thioureaHCID 22262466CH2N2Pb

Product 1

HCID 9992541N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Lead cyanamide (52.6 g.) was added to a solution of N-methyl-N'-[2-(3-isothiazolylmethylthio)ethyl]thiourea (17.7 g.) in acetonitrile (500 ml.) containing dimethylformamide (50 ml.). The mixture was stirred under reflux for 48 hours, then filtered and concentrated. The product was chromatographed on silica gel with ethyl acetate as eluant and recrystallized from isopropyl acetate-ether to give N-cyano-N'-[2-(3-isothiazolylmethylthio)ethyl]-N"-methylguanidine, in a crystalline form, m.p. 63°-64°. Further recrystallization from isopropyl acetate afforded the cyanoguanidine in a crystalline form, m.p. 91°-92°. (Found: C, 42.6; H, 5.2; N, 27.4; S, 23.4. C9H13N5S2 requires: C, 42.3; H, 5.1; H, 27.4; S, 23.1).

Workup

  1. temperatureunder reflux for 48 hours
  2. filtrationfiltered
  3. concentrationconcentrated
  4. customThe product was chromatographed on silica gel with ethyl acetate as eluant
  5. customrecrystallized from isopropyl acetate-ether

Sources & evidence

ORD record
ord-753f0a969afb4a3889ae9e049568e686
Source dataset
uspto-grants-1981_09
Patent number
US04287198

Reaction notes

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