HRID1577281

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CCC(C)(C)c1ccc(OCCCCNC(=O)c2cc(NS(=O)(=O)c3ccc(C(=O)OC)c([N+](=O)[O-])c3)c3ccccc3c2O)c(C(C)(C)CC)c1

HCID20519163

未命名化合物

PRODUCTS

生成物

结构：CCC(C)(C)c1ccc(OCCCCNC(=O)c2cc(NS(=O)(=O)c3ccc(C(=O)OC)c(N)c3)c3ccccc3c2O)c(C(C)(C)CC)c1

HCID20519164

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Intermediate (C) (10.0 g, 13.9 mmoles) was reduced in tetrahydrofuran (100 ml) using Pd/C catalyst at 60 pounds pressure (H2 gas). The temperature rose to 30° C. The catalyst was removed by filtration; the filtrate was concentrated to dryness. Trituration of the residue with methanol produced a solid; yield, 8.3 g (84.9 percent).

WORKUP

后处理

customrose to 30° C
customThe catalyst was removed by filtration
concentrationthe filtrate was concentrated to dryness
customTrituration of the residue with methanol produced a solid
customyield

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-06e7fec586644112896a3096f28c5e99
来源数据集: uspto-grants-1981_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04287292
来源说明: uspto-grants-1981_09

反应 SMILES

[C:1]([C:6]1[CH:47]=[C:46]([C:48]([CH2:51][CH3:52])([CH3:50])[CH3:49])[CH:45]=[CH:44][C:7]=1[O:8][CH2:9][CH2:10][CH2:11][CH2:12][NH:13][C:14]([C:16]1[CH:25]=[C:24]([NH:26][S:27]([C:30]2[CH:35]=[CH:34][C:33]([C:36]([O:38][CH3:39])=[O:37])=[C:32]([N+:40]([O-])=O)[CH:31]=2)(=[O:29])=[O:28])[C:23]2[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:17]=1[OH:43])=[O:15])([CH2:4][CH3:5])([CH3:3])[CH3:2]>O1CCCC1.[Pd]>[NH2:40][C:32]1[CH:31]=[C:30]([S:27]([NH:26][C:24]2[C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:17]([OH:43])=[C:16]([C:14]([NH:13][CH2:12][CH2:11][CH2:10][CH2:9][O:8][C:7]3[CH:44]=[CH:45][C:46]([C:48]([CH2:51][CH3:52])([CH3:49])[CH3:50])=[CH:47][C:6]=3[C:1]([CH2:4][CH3:5])([CH3:3])[CH3:2])=[O:15])[CH:25]=2)(=[O:28])=[O:29])[CH:35]=[CH:34][C:33]=1[C:36]([O:38][CH3:39])=[O:37]