反应详情

Ammonia was passed into a solution of 2,4-dichloro-7,8-dimethoxyquinazoline (287 g., 1.11 moles) in tetrahydrofuran (6 liters) for five hours at room temperature. After stirring an additional hour the suspension was concentrated in vacuo to 2 liters and filtered. The solid was suspended in 2 liters of water, filtered, washed with water and cold methanol. Recrystallization from dimethylformamide/water yielded 164 g. (62%) of pure product, M.P. 300°. (dec.).

1. concentrationwas concentrated in vacuo to 2 liters
2. filtrationfiltered
3. filtrationfiltered
4. washwashed with water and cold methanol
5. customRecrystallization from dimethylformamide/water
6. customyielded 164 g